منابع مشابه
Statins: Newer Roles Including Lipid Lowering Therapy
Statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of HMG-Co A reductase. Apart from the well-known LDL and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. Better understanding of various pleotropic effects of statins has prompted a new s...
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Given a random time, we give some characterizations of the set of martingales for which the stopping theorems still hold. We also investigate how the stopping theorems are modified when we consider arbitrary random times. To this end, we introduce some families of martingales with remarkable properties. DOI: https://doi.org/10.1016/j.spa.2006.06.005 Posted at the Zurich Open Repository and Arch...
متن کاملOptional Stopping
Introduction Suppose you are determined to “prove” that green apples cause cancer. An Optional Stopping strategy (OS) is where you keep looking sampling experimental data until the observed correlation between eating green applies and cancer is significantly different from 0 (where “significantly” means that the null hypothesis is rejected by standard statistical tests). That is, you follow a r...
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Nitric oxide (NO) is an important mediator of host defence and of vascular tone. In septic shock, upregulation of inducible NO synthase leads to the production of vast amounts of NO, which contribute to pathogen elimination but also to inappropriate vaso-dilation and to loss of vascular resistance. Asymmetric dimethyl-arginine (ADMA) is an endogenous inhibitor of NO synthases shown to contribut...
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Sir—The medical community has given almost unquestioning credence to the results of randomised clinical trials. This reliance has led to a discounting of the results of observational studies, animal trials, and basic biological data. Like all forms of investigation, the randomised trial is limited by study design (eg, selection of patients before randomisation, selection of biologically meaning...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000145140.06171.3d